This Presidential Action establishes the White House Great American Recovery Initiative (Initiative) to elevate and coordinate the national response to the addiction crisis, which affects 16.8 percent of the population and costs the United States hundreds of billions annually.

The Initiative will be co-chaired by the Secretary of Health and Human Services and the Senior Advisor for Addiction Recovery, comprising numerous cabinet-level officials and agency heads.

Its goals include coordinating federal programs, increasing public awareness of addiction as a chronic disease, advising agencies on integrating prevention, treatment, and recovery support across various systems (healthcare, criminal justice, housing), and consulting with state and community partners to advance a national effort toward recovery.

This document provides a compilation of numerous individuals nominated by the President to various high-level federal positions, including roles within executive departments, independent agencies, ambassadorships, and U.S. Attorney offices.

The listings specify the nominee's name, their proposed role, the agency or location, and often denote whether the appointment is to fill an expired term, a vacancy, or a newly created position, detailing the necessary Senate confirmation required for these appointments to take effect.

This Presidential Action establishes that Americans deserve better access to medical research on marijuana and cannabidiol (CBD) to address conditions like chronic pain, noting that decades of restrictive federal policy have limited necessary investigations.

The order directs the Attorney General to immediately complete the process of rescheduling marijuana to Schedule III of the Controlled Substances Act (CSA), reflecting the Department of Health and Human Services' recommendation that it has accepted medical use.

Furthermore, the action mandates collaboration with Congress to clarify the regulation of hemp-derived cannabinoid products, including setting THC limits, while tasking HHS and other agencies to develop research models using real-world evidence to improve patient guidance and product safeguards.

A Presidential Action formally designates illicit fentanyl and its core precursor chemicals as Weapons of Mass Destruction (WMD) based on their lethal nature, the national security threat posed by the cartels manufacturing them, and the potential for weaponization.

The order directs relevant executive departments, including Justice, State, Treasury, Defense, and Homeland Security, to take immediate and appropriate actions to implement this designation, involving enhanced investigations, prosecutions, financial sanctions, military support for domestic enforcement, and intelligence gathering using WMD counter-proliferation frameworks.

This Presidential Memorandum directs the Secretary of Health and Human Services and the Director of the Centers for Disease Control and Prevention (CDC) to review the core childhood vaccine recommendations in the United States against the vaccination policies of peer, developed countries, noting the U.S. currently recommends more vaccinations than most international counterparts.

If the review determines that peer country practices are superior based on scientific evidence, the memorandum orders an update to the U.S. core childhood vaccine schedule accordingly, while ensuring continued access to all currently available vaccines.

This Presidential Action establishes the 'Fostering the Future' initiative, led by the Administration, designed to fundamentally modernize the nation's child welfare system.

The order directs the Secretary of Health and Human Services to improve data collection, implement modern technology, and create tools like an annual performance scorecard to enhance child well-being, reduce time in foster care, and accelerate permanent placements.

Furthermore, the order mandates the creation of new educational and employment pathways for youth aging out of the system and addresses policies that may restrict faith-based organizations from participating in federally-funded child welfare programs.

The document announces a modification to presidential actions taken under a national emergency concerning the synthetic opioid supply chain originating from the People's Republic of China (PRC).

Citing PRC commitments to halt the shipment of specific fentanyl precursor chemicals to the United States and control exports globally, the President reduces the additional ad valorem duty on targeted PRC goods from 20 percent to 10 percent, effective November 10, 2025.

The order directs the Secretary of Homeland Security to implement these changes in the Harmonized Tariff Schedule of the United States (HTSUS) and mandates ongoing monitoring of the PRC's compliance, reserving the right to modify the order if commitments are not met.

The President issued a proclamation for National Breast Cancer Awareness Month, acknowledging the fear and heartbreak breast cancer causes and honoring the resilience of those battling it.

The document affirms the Administration's dedication, through efforts like the Make America Healthy Again Commission, to lowering cancer rates and accelerating cures via research.

Furthermore, it urges all Americans to prioritize their health by understanding risk factors, utilizing early detection methods, and implementing preventative measures.